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KMID : 1001020110090030112
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Korean Journal of Urological Oncology
2011 Volume.9 No. 3 p.112 ~ p.118
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Association between LEP Gene Polymorphisms and Prostate Cancer Susceptibility in Korean Men
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Kim Hae-Jong
Lee Jae-Hyouk
Han Jun-Hyun
Lee Ji-Youl
Chang In-Ho
Kim Tae-Hyoung
Kim Kyung-Do
Myung Soon-Chul
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Abstract
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Purpose: Obesity is thought to influence prostate carcinogenesis. Thus, variants in the leptin (LEP) gene could be associated with prostate cancer (PC) risk. Sequence variants in the LEP gene were investigated to determine whether they were associated with PC risk in a Korean study cohort.
Materials and Methods: We evaluated the association between 14 single nucleotide polymorphisms (SNPs) in the LEP gene and PC risk and clinical characteristics (Gleason score and tumor stage) in Korean men (240 case subjects and 223 control subjects).
Results: We observed significantly lower frequencies of rs2278815 and rs4731426 in the patients with PC (18.1%) compared to those in the control group (23.5%) (odds ratio, 0.70; 95% confidence interval, 0.50-0.98, p=0.04). These SNPs were not correlated with clinical stage, prostate specific antigen level, Gleason biopsy score, or age at diagnosis. Our results indicate that the frequencies of rs2278815 and rs4731426 in the LEP gene were significantly lower in Korean patients with PC.
Conslusions: These results suggest that polymorphisms or haplotypes in the LEP gene may influence the risk for PC.
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KEYWORD
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Cancer risk, Leptin, Polymorphism, Prostate cancer
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